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Men 10376 TFA
CAS No. ——
Men 10376 TFA( Neurokinin-2 receptor antagonist TFA )
Catalog No. M29785 CAS No. ——
Men 10376 TFA is an effective and selective tachykinin nk-2 receptor antagonist with a K I value of 4.4 M for the nk-2 receptor in the small intestine of rats.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameMen 10376 TFA
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NoteResearch use only, not for human use.
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Brief DescriptionMen 10376 TFA is an effective and selective tachykinin nk-2 receptor antagonist with a K I value of 4.4 M for the nk-2 receptor in the small intestine of rats.
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DescriptionMen 10376 TFA is an effective and selective tachykinin nk-2 receptor antagonist with a K I value of 4.4 M for the nk-2 receptor in the small intestine of rats.(In Vitro):Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM). Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM).(In Vivo):Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats.
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In Vitro——
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In Vivo——
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SynonymsNeurokinin-2 receptor antagonist TFA
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PathwayOthers
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TargetOther Targets
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RecptorKi: 4.4 μM (NK-2 receptor, rat small intestine)
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight1195.25
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Molecular FormulaC59H69F3N12O12
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Purity>98% (HPLC)
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SolubilityH2O : 1.43 mg/mL (1.20 mM; Need ultrasonic)
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SMILES——
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Chemical NameSequence:Asp-Tyr-{d-Trp}-Val-{d-Trp}-{d-Trp}-Lys-NH2
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
Quartara L, et al. N-terminal truncated analogs of men 10376 as tachykinin NK-2 receptor antagonists. Life Sci. 1992;51(25):1929-36.
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